Women's health support, for every stage.
SHE NO's™ blends Enno:glycia™ fermented soybean with Enno:lacta™ fermented lettuce, both made with our patented NitroLock™ process, for women's formulas at every life stage, from daily wellness to menopause. Its strongest research is in menopause: in a published placebo-controlled trial, this fermented soybean and lettuce pair eased menopause symptom scores in 4 weeks.*
Request a samplePublished human study · 39 women
4 weeks
with the fermented soybean and lettuce pair, menopause symptom scores fell; placebo did not.*
Han et al., Nutrients 2022. Wonkwang University Hospital.
SHE NO's™, in one minute.
Two fermented extracts for women's formulas at every life stage, and the placebo-controlled study behind the pair.
Read the transcript
From your twenties to your sixties and beyond, a woman's body changes with every stage of life. And women want support that keeps up.
More women want gentle, food-based support. And fermented soybean has been part of women's diets in East Asia for centuries.
SHE NO's™ pairs two fermented extracts. Enno:glycia™, from soybean, and Enno:lacta™, from lettuce. Both are made with our patented NitroLock™ fermentation.
Its strongest research is in menopause. In a randomized, placebo-controlled study of thirty nine women, this fermented soybean and lettuce pair lowered menopause symptom scores in just four weeks. With placebo, there was no significant change.
Weight, waist, and blood lipids stayed the same. And at twenty milligrams, SHE NO's™ fits a women's multi, a daily wellness blend, or a menopause formula, with one specification and one certificate of analysis.
SHE NO's™. Women's health support, for every stage.
Two Enno extracts, made for every stage.
Randomized, double-blind, placebo-controlled trial of fermented soybean with fermented lettuce made by the same patented process.*
Menopause symptom scores fell with the pair; placebo showed no significant change.*
Both extracts in one 20 mg serving that fits a women's multi, a daily wellness blend or a menopause formula, with one specification and COA.
What the research found.
Peer-reviewed studies on fermented soybean and lettuce made with the same patented process. The human trial tested the pair at 1,400 mg a day, not SHE NO's™ at its 20 mg serving.
- Menopause symptoms
- Women with menopause symptoms took fermented soybean and lettuce powder or placebo for 4 weeks. The Kupperman menopause index fell significantly with the pair; placebo showed no significant change. Han et al., Nutrients 2022
- Safety in the trial
- No change in body weight, waist, cholesterol or triglycerides; blood counts, liver and kidney markers unchanged.
- Joints (animal and cell)
- Taken by mouth for 14 days in a mouse model of joint inflammation, fermented lettuce extract lowered inflammatory markers, joint-lining inflammation and cartilage breakdown; in human joint-lining cells it calmed growth and migration signals. Park et al., Nutrients 2023
Claim areas for your label
SHE NO's™ suits women's formulas at every life stage. Its human evidence is in menopause, so that is the claim with clinical support. Each claim is listed with the evidence label that must travel with it; claims on a finished product are the brand's responsibility.
- Supports comfort during menopause, including occasional hot flashes.*
- Randomized, double-blind, placebo-controlled trial of the fermented soybean and lettuce pair in 39 women (Han 2022).
- Supports joint comfort.* (Enno:lacta™)
- Animal and cell data on fermented lettuce extract (Park 2023). Use on business materials with that label.
- Contains soy.
- Declare soy as a major food allergen on finished products.
Also sold as singles
Prefer to set the pairing yourself? Enno:glycia™ and Enno:lacta™ are each available on their own at 20 mg.
The documents
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SHE NO's™ sell sheet
2 pages · PDF
The every-stage positioning, the 39-woman placebo-controlled study, where it fits and the specification.
SHE NO's™ technical brief
3 pages · PDF
Both extracts, how they are made, the published research, safety, specification and label listing.
Questions buyers ask
What is inside SHE NO's™?
Enno:glycia™ fermented soybean and Enno:lacta™ fermented lettuce, both made with our patented NitroLock™ process. Blend ratios stay confidential.
How does the published research relate to SHE NO's™?
The trial used fermented soybean and lettuce powder made by the same process at 1,400 mg a day, not SHE NO's™ at its 20 mg serving. Ask us for the specification and the full paper.
Is SHE NO's™ only for menopause?
No. It is made for women's formulas at every life stage, from daily multis and wellness blends to menopause products. The published human study was in women with menopause symptoms, so menopause is where the clinical evidence is; for other formulas, keep claims to general wellness.
Does it contain soy?
Yes. Declare soy as a major food allergen.
Can I buy the two extracts separately?
Yes. Enno:glycia™ and Enno:lacta™ are each available as singles.
Does SHE NO's™ have to appear on my product?
Yes. SHE NO's™ must be listed on both the supplement pack and the label.
Tell us your format and target serving. We send samples, the specification and the published research.