RESOURCE HUB
Dive into the science. Browse our collection of clinical trials and read easy-to-understand summaries highlighting the key findings and proven results supporting our technology.
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Fermented Cabbage for Atopic Dermatitis
Base Ingredient: Cabage
Summary
This document evaluates FCS (fermented cabbage extract containing nitric oxide metabolites with silica) as a potential therapeutic agent for treating atopic dermatitis (AD). In tests on mice, topical application of FCS significantly alleviated AD-like skin lesions, specifically by decreasing clinical severity scores, reducing epidermal thickness, and lowering inflammatory cell infiltration. Its effectiveness is linked to its ability to release a higher peak concentration of Nitric Oxide (857.4 ppb) for a longer duration, as well as its significantly higher levels of GABA and total polyphenols, which actively lower serum levels of inflammatory cytokines (TNF-α and IL-4).
Key Highlights
- Reduces skin inflammation
- Lowers inflammatory cytokines
- Extended nitric-oxide release
- High GABA/polyphenol content
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Fermented Garlic & Blood Pressure
Base Ingredient: Garlic
Summary
This study investigated the anti-hypertensive effects and underlying molecular mechanisms of fermented garlic extract (Fgarlic) on spontaneously hypertensive rats. The extract contains a high concentration of stable nitrite (0.975 mg/ml), which converts to nitric oxide in the body. Both acute and chronic feeding of the extract successfully reduced systolic blood pressure. Researchers determined that this anti-hypertensive effect—along with improved vascular relaxation in the thoracic aorta—is directly mediated through the sGC-cGMP-PKG signaling pathway, as the blood pressure reductions were blocked when an sGC inhibitor was introduced.
Key highlights:
Key Highlights
High stable nitrite
Reduces blood pressure
Activates sGC-cGMP-PKG pathway
Improves aortic relaxation
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Fermented Garlic & Pulmonary Hypertension
Base Ingredient: Garlic
Summary
Researchers investigated the effects of fermented garlic extract (FGE) on pulmonary hypertension using a monocrotaline (MCT)-treated rat model. MCT treatment typically causes endothelial damage, pulmonary fibrosis, increased right ventricle weight, and elevated systolic pressure. The study found that feeding the rats FGE successfully attenuated all of these negative cardiovascular effects. FGE decreased the expression of inflammatory proteins (VCAM-1 and MMP-9) while increasing beneficial proteins (PKG and eNOS) in the lungs, with the overall protective mechanism being mediated through the NO-sGC-PKG pathway
Key Highlights
- Attenuates pulmonary negative effects
- Activates NO-sGC-PKG pathway
- Decreases inflammatory proteins
- Increases beneficial proteins
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Fermented Garlic for Enhanced Blood Flow
Base Ingredient: Garlic
Summary
This randomized controlled trial evaluated the acute effects of nitrite-containing Fermented Garlic Extract (FGE) on blood flow, blood pressure, and carotid artery velocity in healthy human adults. Because FGE increases the bioavailability of Nitric Oxide via its nitrite metabolite, it acts as a potent vasodilator. Participants who ingested FGE experienced significant positive changes in blood pressure and common carotid artery velocity within 30 to 60 minutes. Additionally, FGE ingestion led to significant increases in regional cerebral blood flow and peripheral blood flow (evidenced by rising body surface temperatures) without producing any detectable clinical side effects.
Key Highlights
- Improves artery velocity
- Increases blood flow
- No reported side-effects
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Botanical NO Mixture for Dementia
Base Ingredient: Garlic
Summary
Addressing the link between nitric oxide (NO) deficiency and Vascular Dementia (VD), this study tested a botanical mixture (BM) comprising fermented garlic, fermented Scutellaria baicalensis, and Rhodiola rosea on a VD rat model. The goal was to use the NO metabolites in the BM to increase NO bioavailability. The treatment successfully alleviated cognitive deficits and enhanced neural plasticity by boosting long-term potentiation. Furthermore, the mixture protected the brain by reducing neuron cell death, lowering oxidative stress, decreasing neuroinflammation markers (GFAP), and increasing levels of parvalbumin and Brain-Derived Neurotrophic Factor (BDNF).
Key Highlights
Enhances neural plasticity
Reduces neuron death
Increases BDNF levels
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Antidiabetic Fermented Lettuce Noodles
Base Ingredient: Lettuce
Summary
This study examined the antidiabetic properties of formulating functional foods, specifically noodles, with fermented lettuce extract (FLE). Analysis showed that FLE noodles contained approximately six times more GABA, alongside higher total polyphenols and superior antioxidant activity compared to standard noodles. When tested in vivo on a diabetic mouse model, the mice fed FLE noodles exhibited significantly lower blood glucose levels and reduced insulin resistance. Metabolomic profiling of the serum indicated that FLE actively altered key metabolic pathways, including glycolysis, purine metabolism, and amino acid metabolism, supporting its use as a potent antidiabetic food additive.
Key Highlights
- Superior GABA/polyphenol content
- Reduces insulin resistance
- Optimizes metabolic pathways
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Fermented Lettuce & Starch Retrogradation
Base Ingredient: Lettuce
Summary
Starch retrogradation (staling) negatively impacts the texture and quality of starchy foods over time. This study investigated how adding fermented lettuce extract (FLE) mitigates this process in garaetteok (Korean rice cake) during cold storage. Using advanced analyses (RVA, DSC, SEM, and texture analysis), researchers found that FLE effectively reduced the peak viscosity, onset temperatures, and enthalpy changes of the rice flour. Consequently, FLE-treated rice cakes maintained a significantly softer texture with less hardness over time, and microscopic imaging revealed their surfaces were noticeably less cracked and porous compared to untreated controls.
Key Highlights
- Lowers peak viscosity
- Maintains starch softness
- Reduces surface cracking
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Fermented Lettuce for Arthritis
Base Ingredient: Lettuce
Summary
This study investigated the therapeutic effects and underlying mechanisms of stable nitric oxide-containing fermented lettuce extract (FLE) on rheumatoid arthritis (RA). Using a collagen-induced arthritis (CIA) mouse model, researchers found that 14 days of oral FLE administration successfully inhibited RA development by suppressing pro-inflammatory cytokine production, reducing synovial inflammation, and preventing cartilage degradation—yielding therapeutic effects comparable to the common RA drug methotrexate. In vitro tests on human cells further revealed that FLE works by suppressing the TGF-β/Smad signaling pathway, inhibiting matrix-degrading enzymes, and inducing cellular autophagy.
Key Highlights
Inhibits RA development
Reduces synovial inflammation
Suppresses TGF-β/Smad pathway
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Soybean-Lettuce for Menopause Symptoms
Base Ingredient: Soybean-Lettuce
Summary
With concerns rising over the side effects of traditional hormone replacement therapy, this four-week randomized, double-blind clinical trial evaluated a natural alternative: a fermented soybean-lettuce extract (SLE) rich in nitric oxide metabolites. Testing 39 adult women experiencing menopausal syndrome, researchers found that the group taking SLE saw a highly significant decrease in symptom severity (measured via the Kupperman index), whereas the placebo group saw no improvement. Importantly, SLE successfully alleviated these symptoms safely, causing no adverse side effects or negative changes to the participants’ body mass index, blood lipid profiles, or baseline hormone levels.
Key Highlights
- Reduces menopausal symptoms
- No metabolic alterations
- Safe, side-effect-free
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